Figuring out the “dose-response relationship” of a new compound is something a pharmaceutical company does from the start of trials in human subjects, as it prepares a new drug application for the F.D.A. Too little of a powerful drug means that it won’t work. Too much means that it might do more harm than good. The amount of active ingredient in a pill and the metabolic path that the ingredient takes after it enters your body—these are things that drugmakers will have painstakingly mapped out before the product comes on the market, with a tractor-trailer full of supporting documentation.
Buy marijuana Brampton, apparently, we’re still waiting for this information. It’s hard to study a substance that until very recently has been almost universally illegal. And the few studies we do have were done mostly in the nineteen-eighties and nineties, when cannabis was not nearly as potent as it is now. Because of recent developments in plant breeding and growing techniques, the typical concentration of THC, the psychoactive ingredient in marijuana, has gone from the low single digits to more than twenty per cent—from a swig of near-beer to a tequila shot.
Are users smoking less, to compensate for the drug’s new potency? Or simply getting more stoned, more quickly? Is high-potency cannabis more of a problem for younger users or for older ones? For some drugs, the dose-response curve is linear: twice the dose creates twice the effect. For other drugs, it’s nonlinear: twice the dose can increase the effect tenfold, or hardly at all. Which is true for cannabis? It also matters, of course, how cannabis is consumed. It can be smoked, vaped, eaten, or applied to the skin. How are absorption patterns affected?
Marijuana: A common street and recreational drug that comes from the marijuana plant: the hemp plant cannabis sativa. The pharmacologically active ingredient in marijuana is tetra-hydro-cannabinol (THC). Marijuana is used to heighten perception, affect mood, and relax. Many people think marijuana is harmless, but it is not. Signs of marijuana use include red eyes, lethargy, and uncoordinated body movements. The long-term effects may include decrease in motivation and harmful effects on the brain, heart, lungs, and reproductive system. People who smoke marijuana are also at increased risk of developing cancer of the head and neck. A pharmaceutical product, Marinol, that contains synthetic THC, is available as a prescription medication. It comes in the form of a pill (eliminating the harmful and cancer-causing chemicals present when marijuana is smoked) and is used to relieve the nausea and vomiting associated with chemotherapy for cancer patients and to treat loss of appetite in AIDS patients.